Synthesis and biological evaluation of 2,5-dihydropyrazolo[4,3-c]quinolin-3-ones, a novel series of PDE 4 inhibitors with low emetic potential and antiasthmatic properties

Author:

Crespo Marı́a I,Gràcia Jordi,Puig Carles,Vega Armando,Bou Josep,Beleta Jordi,Doménech Teresa,Ryder Hamish,Segarra Vı́ctor,Palacios José M

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference13 articles.

1. Phosphodiesterase 4 and tolerance to β2-adrenoceptor agonists in asthma

2. Design, Synthesis, and Biological Activities of New Thieno[3,2-d]pyrimidines as Selective Type 4 Phosphodiesterase Inhibitors

3. Bou, J.; Beleta, J.; Llupià, J.; Cardelús, I.; Miralpeix, M.; Puig, J.; Doménech, T.; Salcedo, C.; Gras, J.; Fernández, A. G.; Llenas, J.; Berga, P.; Gristwood, R. W.; Palacios, J. M. In Third International Conference on Cyclic Nucleotide Phosphodiesterase: From Genes to Therapies; Glasgow, July 1996.

4. (a) GRID, version 14; Molecular Discovery Limited, Oxford OX2 9LL, UK.

5. (b) Goodford P. J. J. Med. Chem. 1985, 28, 849.

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