Phenyl benzenesulfonamides are novel and selective 5-HT6 antagonists: identification of N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide (SB-357134)-Reference-Cited by-同舟云学术

Phenyl benzenesulfonamides are novel and selective 5-HT6 antagonists: identification of N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide (SB-357134)

Published:2001-01 Issue:1 Volume:11 Page:55-58
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Bromidge Steven M,Clarke Stephen E,Gager Tracey,Griffith Kerry,Jeffrey Phillip,Jennings Andrew J,Joiner Graham F,King Frank D,Lovell Peter J,Moss Stephen F,Newman Helen,Riley Graham,Rogers Derek,Routledge Carol,Serafinowska Halina,Smith Douglas R

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference6 articles.

1. 5-ht6 Receptors as Emerging Targets for Drug Discovery

2. Characterization of SB-271046: A potent, selective and orally active 5-HT6 receptor antagonist

3. Rogers, D. C.; Robinson, T. L.; Quilter, C. A.; Hunter, A. J.; Routledge, C.; Hagan, J. J. Br. J. Pharmacol. 1999, 127 Proc. Suppl., 22 pp.

4. 5-Chloro-N-(4-methoxy-3-piperazin-1-yl- phenyl)-3-methyl-2-benzothiophenesulfon- amide (SB-271046): A Potent, Selective, and Orally Bioavailable 5-HT6 Receptor Antagonist

5. In vivo effects of the 5-HT6 antagonist SB-271046 on striatal and frontal cortex extracellular concentrations of noradrenaline, dopamine, 5-HT, glutamate and aspartate

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