Inhibitors of bacterial tyrosyl tRNA synthetase: synthesis of four stereoisomeric analogues of the natural product SB-219383

Author:

Berge John M,Copley Royston C.B,Eggleston Drake S,Hamprecht Dieter W,Jarvest Richard L,Mensah Lucy M,O'Hanlon Peter J,Pope Andrew J

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference11 articles.

1. SB-219383, a Novel Tyrosyl tRNA Synthetase Inhibitor from a Micromonospora sp. I. Fermentation, Isolation and Properties.

2. Recent Advances in the Chemistry of Anti-infective Agents;Walker,1993

3. SB-219383, a Novel Tyrosyl tRNA Synthetase Inhibitor from a Micromonospora sp. II. Structure Determination.

4. Berge, J. M.; Broom, N. J. P.; Houge-Frydrych, C. S. V.; Jarvest, R. L.; Mensah, L. M.; McNair, D. J.; O'Hanlon, P. J.; Pope, A. J.; Rittenhouse, S., submitted for publication.

5. For examples of sugar derived nitrones see e. g.: Herczegh, P.; Kovács, I.; Szilágyi, L.; Varga, T.; Dinya, Z.; Sztaricskai, F. Tetrahedron Lett. 1993, 34, 1211. Van den Broek, L. A. G. M. Tetrahedron 1996, 52, 4467. Ishikawa, T.; Tajima, Y.; Fukui, M.; Saito, S. Angew. Chem., Int. Ed. Engl. 1996, 35, 1863.

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