Preparation of the geometric isomers of DDC, DDA, D4C and D4T as potential anti-HIV agents-Reference-Cited by-同舟云学术

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Preparation of the geometric isomers of DDC, DDA, D4C and D4T as potential anti-HIV agents

Published:1991-01 Issue:1 Volume:1 Page:65-68
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Mansuri Muzammil M.,Farina Vittorio,Starrett John E.,Benigni Daniel A.,Brankovan Vera,Martin John C.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference15 articles.

1. Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) by 2',3'-dideoxynucleosides.

2. New acquisitions in the development of anti-HIV agents

3. Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase.

4. Metabolic pathways for the activation of the antiretroviral agent 2',3'-dideoxyadenosine in human lymphoid cells.

5. 1-(2,3-Dideoxy-.beta.-D-glycero-pent-2-enofuranosyl)thymine. A highly potent and selective anti-HIV agent

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