MASP-2 and MASP-3 inhibitors block complement activation, inflammation, and microvascular stasis in a murine model of vaso-occlusion in sickle cell disease

Author:

Belcher John D.,Nguyen Julia,Chen Chunsheng,Abdulla Fuad,Conglin Ruan,Ivy Zalaya K.,Cummings Jason,Dudler Thomas,Vercellotti Gregory M.

Publisher

Elsevier BV

Subject

Biochemistry (medical),Public Health, Environmental and Occupational Health,General Medicine,Physiology (medical)

Reference70 articles.

1. The multifaceted role of ischemia/reperfusion in sickle cell anemia;Hebbel;J Clin Invest,2020

2. Serum complement activity in normal individuals and patients with sickle cell hemoglobin abnormalities;Francis;Am J Med Technol,1967

3. In vitro evidence of complement activation in patients with sickle cell disease;Gavriilaki;Haematologica,2017

4. Factor H interferes with the adhesion of sickle red cells to vascular endothelium: a novel disease-modulating molecule;Lombardi;Haematologica,2019

5. Intravascular hemolysis activates complement via cell-free heme and heme-loaded microvesicles;Merle;JCI Insight,2018

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