G-quadruplex deconvolution with physiological mimicry enhances primary screening: Optimizing the FRET Melt2 assay

Author:

Morgan Rhianna K.,Psaras Alexandra Maria,Lassiter Quinea,Raymer Kelsey,Brooks Tracy A.

Funder

National Institutes of Health

National Cancer Institute

Publisher

Elsevier BV

Subject

Genetics,Molecular Biology,Biochemistry,Structural Biology,Biophysics

Reference33 articles.

1. Genome-wide computational and expression analyses reveal G-quadruplex DNA motifs as conserved cis-regulatory elements in human and related species;Verma;J. Med. Chem.,2008

2. High-throughput sequencing of DNA G-quadruplex structures in the human genome;Chambers;Nat. Biotechnol.,2015

3. Targeting MYC expression through G-Quadruplexes;Brooks;Genes Cancer,2010

4. Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?;Balasubramanian;Nat. Rev. Drug Discov.,2011

5. T.G. Hao, V.C.; Brooks, T.A., Nucleic acid clamps engineered to detect and stabilize the MYC G-quadruplex: a new therapeutic approach, Nucleic Acids Res., (2016).

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