Author:
Shi Hongxin,Liu Huazhang,Bloch Robert,Mandville Gérard
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Catalysis
Reference15 articles.
1. trans-2,5-Bis-(3,4,5-trimethoxyphenyl)tetrahydrofuran. An orally active specific and competitive receptor antagonist of platelet activating factor.
2. Palladium-catalyzed synthesis of trans-2,5-diaryltetrahydrofurans, potent platelet-activating factor antagonists
3. Synthesis of PAF antagonist MK-287
4. Development, synthesis, and biological evaluation of (-)-trans-(2S,5S)-2-[3-[(2-oxopropyl)sulfonyl]-4-n-propoxy-5-(3-hydroxypropoxy)-phenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran, a potent orally active platelet-activating factor (PAF) antagonist and its water-soluble prodrug phosphate ester
5. For syntheses of analogs of MK-287, see for example: (a) Cai, X.; Scannel, R. T.; Yaeger, D.; Hussoin, M. S.; Killian, D. B.; Qian, C.; Eckman, J.; Hwang, S. B.; Libertine-Garahan, L.; Yeh, L. G.; Ip, S. H.; Shen, T. Y. J. Med. Chem. 1998, 41, 1970–1979; (b) Ram, B.; Balram, B.; Prakash, P. K. S. Tetrahedron 1999, 55, 10163–10172.
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