Design, synthesis and biological evaluation of novel pyrrolo[2,3-d]pyrimidine as tumor-targeting agents with selectivity for tumor uptake by high affinity folate receptors over the reduced folate carrier-Reference-Cited by-同舟云学术

Design, synthesis and biological evaluation of novel pyrrolo[2,3-d]pyrimidine as tumor-targeting agents with selectivity for tumor uptake by high affinity folate receptors over the reduced folate carrier

Published:2020-06 Issue:12 Volume:28 Page:115544
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Golani Lalit K.,Islam Farhana,O'Connor Carrie,Dekhne Aamod S.,Hou Zhanjun,Matherly Larry H.,Gangjee Aleem

Funder

Institutes of Health

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

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4. Human reduced folate carrier: translation of basic biology to cancer etiology and therapy;Matherly;Cancer Metastasis Rev,2007

5. Distribution, functionality and gene regulation of folate receptor isoforms: implications in targeted therapy;Elnakat;Adv Drug Deliv Rev,2004

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