Structure-based screening combined with computational and biochemical analyses identified the inhibitor targeting the binding of DNA Ligase 1 to UHRF1-Reference-Cited by-同舟云学术

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Structure-based screening combined with computational and biochemical analyses identified the inhibitor targeting the binding of DNA Ligase 1 to UHRF1

Published:2021-12 Issue: Volume:52 Page:116500
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Kori Satomi,Shibahashi Yuki,Ekimoto Toru,Nishiyama Atsuya,Yoshimi Sae,Yamaguchi Kosuke,Nagatoishi Satoru,Ohta Masateru,Tsumoto Kouhei,Nakanishi Makoto,Defossez Pierre-Antoine,Ikeguchi Mitsunori,Arita Kyohei

Funder

Takeda Science Foundation

Japan Agency for Medical Research and Development

Yokohama Shiritsu Daigaku

Japan Society for the Promotion of Science

ARC Foundation for Cancer Research

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference78 articles.

1. Accumulation of Genetic and Epigenetic Alterations in Normal Cells and Cancer Risk;Takeshima;NPJ Precis Oncol,2019

2. Epigenetic Therapies for Cancer;Bates;N Engl J Med,2020

3. Function and Information Content of DNA Methylation;Schübeler;Nature,2015

4. A DNA Methylation Fingerprint of 1628 Human Samples;Fernandez;Genome Res,2012

5. Navigating the DNA Methylation Landscape of Cancer;Nishiyama;Trends Genet,2021

Cited by 10 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells;Nature Communications;2024-04-05

2. Chemical rewiring of ubiquitination by degraders and their selectivity routes;Nature Structural & Molecular Biology;2024-02

3. Targeting Epigenetic Readers Using Small Molecule Binders and PROTAC Degraders;Interdisciplinary Cancer Research;2024

4. Mechanistic insights into UHRF1‑mediated DNA methylation by structure‑based functional clarification of UHRF1 domains (Review);Oncology Letters;2023-11-02

5. Pharmacological perturbation of the phase-separating protein SMNDC1;Nature Communications;2023-08-16

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