Modified 2,4-diaminopyrimidine-based dihydrofolate reductase inhibitors as potential drug scaffolds against Bacillus anthracis-Reference-Cited by-同舟云学术

Modified 2,4-diaminopyrimidine-based dihydrofolate reductase inhibitors as potential drug scaffolds against Bacillus anthracis

Published:2015-01 Issue:1 Volume:23 Page:203-211
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Nammalwar Baskar,Bourne Christina R.,Wakeham Nancy,Bourne Philip C.,Barrow Esther W.,Muddala N. Prasad,Bunce Richard A.,Berlin K. Darrell,Barrow William W.

Funder

National Institutes of Allergy and Infectious Diseases

NSF

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference28 articles.

1. New Developments in Vaccines, Inhibitors of Anthrax Toxins, and Antibiotic Therapeutics for Bacillus anthracis

2. Proliferation of weapons of mass destruction: Assessing the Risks. Available online at: http://www.au.af.mil/au/awc/awcgate/ota/9341.pdf.

3. Crystal Structure of Bacillus anthracis Dihydrofolate Reductase with the Dihydrophthalazine-Based Trimethoprim Derivative RAB1 Provides a Structural Explanation of Potency and Selectivity

4. In Vitro Efficacy of New Antifolates against Trimethoprim-Resistant Bacillus anthracis

5. Antibiotic resistance is ancient

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