Synthesis, SAR studies, and pharmacological evaluation of 3-anilino-4-(3-indolyl) maleimides with conformationally restricted structure as orally bioavailable PKCβ-selective inhibitors-Reference-Cited by-同舟云学术

Synthesis, SAR studies, and pharmacological evaluation of 3-anilino-4-(3-indolyl) maleimides with conformationally restricted structure as orally bioavailable PKCβ-selective inhibitors

Published:2006-09 Issue:17 Volume:14 Page:5781-5794
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Tanaka Masahiro,Sagawa Shoichi,Hoshi Jun-ichi,Shimoma Fumito,Yasue Katsutaka,Ubukata Minoru,Ikemoto Tomoyuki,Hase Yasunori,Takahashi Mitsuru,Sasase Tomohiko,Ueda Nobuhisa,Matsushita Mutsuyoshi,Inaba Takashi

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference36 articles.

1. Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation.

2. Protein kinase C activation and the development of diabetic complications.

3. Amelioration of Vascular Dysfunctions in Diabetic Rats by an Oral PKC β Inhibitor

4. A protein kinase C-beta-selective inhibitor ameliorates neural dysfunction in streptozotocin-induced diabetic rats.

Cited by 42 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Ca(II)-Catalyzed Cascade Reaction of Tryptamines with Propargylic Alcohols: Temperature-Driven Ring Opening and Closing via the Allene Migration Pathway for the Synthesis of Pyrrolo[1,2-a]indoles;Organic Letters;2024-02-02

2. Radical Cascade Cyclization of Unactivated Alkene-Tethered Indoles with Aryldiazonium Salt and Sodium Metabisulfite to Access Azo- and Sulfonylated-2,3-Dihyro-1H-pyrrolo[1,2-a]indoles;The Journal of Organic Chemistry;2023-06-28

3. Quantum-Chemical Study of Keto–Enol Equilibrium and Global Electrophilicity of Hydroxymaleimide Derivatives;Doklady Physical Chemistry;2023-02

4. Synthesis of 2-carboxyaniline-substituted maleimides from 2′-nitrochalcones;Organic & Biomolecular Chemistry;2023

5. DFT STUDY OF KETO-ENOL EQUILIBRIUM AND GLOBAL ELECTROPHILICITY OF HYDROXYMALEIMIDE DERIVATIVES;Доклады Российской академии наук. Химия, науки о материалах;2023-01-01