Discovery and optimization of 1,7-disubstituted-2,2-dimethyl-2,3-dihydroquinazolin-4(1H)-ones as potent and selective PKCθ inhibitors-Reference-Cited by-同舟云学术

Discovery and optimization of 1,7-disubstituted-2,2-dimethyl-2,3-dihydroquinazolin-4(1H)-ones as potent and selective PKCθ inhibitors

Published:2016-06 Issue:11 Volume:24 Page:2466-2475
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Katoh Taisuke,Takai Takafumi,Yukawa Takafumi,Tsukamoto Tetsuya,Watanabe Etsurou,Mototani Hideyuki,Arita Takeo,Hayashi Hiroki,Nakagawa Hideyuki,Klein Michael G.,Zou Hua,Sang Bi-Ching,Snell Gyorgy,Nakada Yoshihisa

Funder

National Institutes of Health

National Institute of General Medical Sciences

U.S. Department of Energy

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference35 articles.

1. PKC and the control of localized signal dynamics

2. Protein kinase Cθ: a new essential superstar on the T-cell stage

3. Protein Kinase C θ Affects Ca2+ Mobilization and NFAT Activation in Primary Mouse T Cells

4. PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

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