Discovery and preclinical evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as single agents with microtubule targeting effects along with triple-acting angiokinase inhibition as antitumor agents-Reference-Cited by-同舟云学术

Discovery and preclinical evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as single agents with microtubule targeting effects along with triple-acting angiokinase inhibition as antitumor agents

Published:2017-01 Issue:2 Volume:25 Page:545-556
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Pavana Roheeth Kumar,Choudhary Shruti,Bastian Anja,Ihnat Michael A.,Bai Ruoli,Hamel Ernest,Gangjee Aleem

Funder

National Institutes of Health

NCI

NSF

Duquesne University Adrian Van Kaam Chair in Scholarly Excellence

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference63 articles.

1. Angiogenesis in cancer and other diseases

2. Molecular mechanisms and clinical applications of angiogenesis

3. Vascular endothelial growth factor and its receptor system: physiological functions in angiogenesis and pathological roles in various diseases

4. Rapid vascular regrowth in tumors after reversal of VEGF inhibition

5. Discontinuation of anti-VEGF cancer therapy promotes metastasis through a liver revascularization mechanism

Cited by 13 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Interpreting drug synergy in breast cancer with deep learning using target-protein inhibition profiles;BioData Mining;2024-02-29

2. Epidermal growth factor receptor dual-target inhibitors as a novel therapy for cancer: A review;International Journal of Biological Macromolecules;2023-12

3. Five-membered ring fused pyrimidine-based derivatives and their biological properties;Fused Pyrimidine-Based Drug Discovery;2023

4. Magnetic Fe3O4 nanoparticles in melamine-based ternary deep eutectic solvent as a novel eco-compatible system for green synthesis of pyrido[2,3-d]pyrimidine derivatives;Journal of Molecular Structure;2022-12

5. Recent progress on vascular endothelial growth factor receptor inhibitors with dual targeting capabilities for tumor therapy;Journal of Hematology & Oncology;2022-07-07