Synthesis and biological evaluation of 3-aminoisoquinolin-1(2H)-one based inhibitors of the dual-specificity phosphatase Cdc25B-Reference-Cited by-同舟云学术

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Synthesis and biological evaluation of 3-aminoisoquinolin-1(2H)-one based inhibitors of the dual-specificity phosphatase Cdc25B

Published:2015-06 Issue:12 Volume:23 Page:2810-2818
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

George Rosenker Kara M.,Paquette William D.,Johnston Paul A.,Sharlow Elizabeth R.,Vogt Andreas,Bakan Ahmet,Lazo John S.,Wipf Peter

Funder

National Institutes of Health

Institute for Mental Health

Institute for General Medical Sciences

University of Pittsburgh Cancer Institute Chemical Biology Facility

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference36 articles.

1. The therapeutic potential of phosphatase inhibitors

2. CDC25 phosphatases in cancer cells: key players? Good targets?

3. Dual-specificity phosphatases as targets for antineoplastic agents

4. Is Cdc25 a Druggable Target?

5. Crystal structure of the catalytic subunit of Cdc25B required for G 2 /M phase transition of the cell cycle 1 1Edited by I. A. Wilson

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2. Design, Synthesis, and In Vitro Mitotic Evaluation of 3‐Amino‐Isoquinolinones as Anticancer Agents;ChemistrySelect;2022-11-10

3. CDC25B Inhibition by Menadione: A Potential New Therapeutical Approach;Anti-Cancer Agents in Medicinal Chemistry;2022-10

4. Development of an automated screen for Kv7.2 potassium channels and discovery of a new agonist chemotype;Bioorganic & Medicinal Chemistry Letters;2022-09

5. Comprehensive Analysis and Experimental Validation of a Novel Estrogen/Progesterone-Related Prognostic Signature for Endometrial Cancer;Journal of Personalized Medicine;2022-05-31

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