Design, synthesis and preliminary SAR studies of novel N-arylmethyl substituted piperidine-linked aniline derivatives as potent HIV-1 NNRTIs-Reference-Cited by-同舟云学术

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Design, synthesis and preliminary SAR studies of novel N-arylmethyl substituted piperidine-linked aniline derivatives as potent HIV-1 NNRTIs

Published:2014-01 Issue:1 Volume:22 Page:633-642
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Zhang Lingzi,Zhan Peng,Chen Xuwang,Li Zhenyu,Xie Zhoumeng,Zhao Tong,Liu Huiqing,De Clercq Erik,Pannecouque Christophe,Balzarini Jan,Liu Xinyong

Funder

National Natural Science Foundation of China

Key Project of NSFC for International Cooperation

Research Fund for the Doctoral Program of Higher Education of China

Key Project of The International Cooperation, Ministry of Science and Technology of China

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference31 articles.

1. Global treatment report and presentation, WHO, (2013).

2. The role of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the therapy of HIV-1 infection1Presented at the Eleventh International Conference on Antiviral Research, San Diego, CA, 5–10 April 1998.1

3. Molecular basis of fidelity of DNA synthesis and nucleotide specificity of retroviral reverse transcriptases

4. Structural basis for drug resistance mechanisms for non-nucleoside inhibitors of HIV reverse transcriptase

5. Novel HIV-1 reverse transcriptase inhibitors

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1. Medicinal chemistry perspectives on the development of piperazine-containing HIV-1 inhibitors;Bioorganic & Medicinal Chemistry;2024-02

2. Bilastine Based Drugs as SARS-CoV-2 Protease Inhibitors: Molecular Docking, Dynamics, and ADMET Related Studies;Orbital: The Electronic Journal of Chemistry;2022-03-30

3. Combination of 2D and 3D-QSAR studies on DAPY and DANA derivatives as potent HIV-1 NNRTIs;Journal of Molecular Structure;2022-02

4. Recent progress in HIV-1 inhibitors targeting the entrance channel of HIV-1 non-nucleoside reverse transcriptase inhibitor binding pocket;European Journal of Medicinal Chemistry;2019-07

5. Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles;Journal of Medicinal Chemistry;2019-02-05

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