3-Hydroxy-1,5-dihydro-pyrrol-2-one derivatives as advanced inhibitors of HIV integrase

Author:

Kawasuji Takashi,Fuji Masahiro,Yoshinaga Tomokazu,Sato Akihiko,Fujiwara Tamio,Kiyama Ryuichi

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference5 articles.

1. Novel aryl diketo-containing inhibitors of HIV-1 integrase

2. Structure and Function of HIV-1 Integrase

3. Yoshinaga, T.; Sato, A.; Fujishita, T.; Fujiwara, T. S-1360: In Vitro Activity of a New HIV-1 Integrase Inhibitor in Clinical Development. In Ninth Conference on Retroviruses and Opportunistic Infections, Seattle, Washington, USA, 24–28 February 2002. Abstracts, 55p, no. 8.

4. A platform for designing HIV integrase inhibitors. Part 1: 2-Hydroxy-3-heteroaryl acrylic acid derivatives as novel HIV integrase inhibitor and modeling of hydrophilic and hydrophobic pharmacophores

5. A platform for designing HIV integrase inhibitors. Part 2: A two-metal binding model as a potential mechanism of HIV integrase inhibitors

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