Synthesis and evaluation of 1,2,3,4-tetrahydro-1-acridone analogues as potential dual inhibitors for amyloid-beta and tau aggregation-Reference-Cited by-同舟云学术

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Synthesis and evaluation of 1,2,3,4-tetrahydro-1-acridone analogues as potential dual inhibitors for amyloid-beta and tau aggregation

Published:2018-09 Issue:16 Volume:26 Page:4693-4705
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Lv Peng,Xia Chun-Li,Wang Ning,Liu Zhen-Quan,Huang Zhi-Shu,Huang Shi-Liang

Funder

Natural Science Foundation of China

Specialized Research Fund for the Doctoral Program of Higher Education of China

Natural Science Foundation of Guangdong Province

Guangdong Provincial Key Laboratory of Construction Foundation

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference29 articles.

1. Memory retrieval by activating engram cells in mouse models of early Alzheimer’s disease;Roy;Nature,2016

2. Correlation of specific amyloid-beta oligomers with tau in cerebrospinal fluid from cognitively normal older adults;Handoko;JAMA Neurol,2013

3. Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome;Oddo;Neuron,2004

4. Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer’s disease mouse model;Roberson;Science,2007

5. Probing the biology of Alzheimer’s disease in mice;Ashe;Neuron,2010

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