1,2,4-Thiadiazole acyclic nucleoside phosphonates as inhibitors of cysteine dependent enzymes cathepsin K and GSK-3β-Reference-Cited by-同舟云学术

1,2,4-Thiadiazole acyclic nucleoside phosphonates as inhibitors of cysteine dependent enzymes cathepsin K and GSK-3β

Published:2021-02 Issue: Volume:32 Page:115998
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Pomeislová Alice,Otmar Miroslav,Rubešová Petra,Benýšek Jakub,Matoušová Marika,Mertlíková-Kaiserová Helena,Pohl Radek,Poštová Slavětínská Lenka,Pomeisl Karel,Krečmerová Marcela

Funder

European Regional Development Fund

Ministerstvo Školství, Mládeže a Tělovýchovy

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference40 articles.

1. 1,2,4-Thiadiazole: A novel Cathepsin B inhibitor

2. Advances in the discovery of cathepsin K inhibitors on bone resorption

3. Cathepsin K Inhibitors for Osteoporosis: Biology, Potential Clinical Utility, and Lessons Learned

4. Pharmacological inhibition of cathepsin K: A promising novel approach for postmenopausal osteoporosis therapy

5. Bicyclic peptidomimetic tetrahydrofuro[3,2-b]pyrrol-3-one and hexahydrofuro[3,2-b]pyridine-3-one based scaffolds: synthesis and cysteinyl proteinase inhibition

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