Design, synthesis and biological evaluation of novel 2,4-disubstituted quinazoline derivatives targeting H1975 cells via EGFR-PI3K signaling pathway-Reference-Cited by-同舟云学术

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Design, synthesis and biological evaluation of novel 2,4-disubstituted quinazoline derivatives targeting H1975 cells via EGFR-PI3K signaling pathway

Published:2021-08 Issue: Volume:43 Page:116265
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Wang Zhengjie,Liu Limin,Dai Honglin,Si Xiaojie,Zhang Luye,Li Erdong,Yang Zhang,Chao Gao,Zheng Jiaxin,Ke Yu,Lihong Shan,Zhang Qiurong,Liu Hongmin

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference32 articles.

1. Architecture and membrane interactions of the EGF receptor;Arkhipov;Cell,2013

2. The EGFR family: not so prototypical receptor tyrosine kinases;Lemmon;Cold Spring Harb Perspect Biol,2014

3. Determination of EGFR signaling output by opposing gradients of BMP and JAK/STAT activity;Fregoso Lomas;Curr Biol,2016

4. Oncogenic mutations counteract intrinsic disorder in the EGFR kinase and promote receptor dimerization;Shan;Cell,2012

5. Knockdown of ADAM17 inhibits cell proliferation and increases oxaliplatin sensitivity in HCT-8 colorectal cancer through EGFR-PI3K-AKT activation;Zhang;Biochem Biophys Res Commun,2018

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3. Bioactive Amino-Quinazolines: Synthesis and Therapeutic Applications;Journal of the Brazilian Chemical Society;2024

4. Design, synthesis, and antimicrobial evaluation of 2‐aminothiazole derivatives bearing the 4‐aminoquinazoline moiety against plant pathogenic bacteria and fungi;Pest Management Science;2023-07-27

5. Design, synthesis and antitumor activity evaluation of 2,4,6-trisubstituted quinazoline derivatives containing piperidine moiety;Medicinal Chemistry Research;2023-07-15

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