Design, synthesis, and biological activity of novel factor Xa inhibitors: Improving metabolic stability by S1 and S4 ligand modification-Reference-Cited by-同舟云学术

Design, synthesis, and biological activity of novel factor Xa inhibitors: Improving metabolic stability by S1 and S4 ligand modification

Published:2006-03 Issue:5 Volume:14 Page:1309-1330
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Komoriya Satoshi,Kobayashi Shozo,Osanai Ken,Yoshino Toshiharu,Nagata Tsutomu,Haginoya Noriyasu,Nakamoto Yumi,Mochizuki Akiyoshi,Nagahara Takayasu,Suzuki Makoto,Shimada Takashi,Watanabe Kengo,Isobe Yumiko,Furugoori Taketoshi

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference41 articles.

1. Role of Thrombin Compared With Factor Xa in the Procoagulant Activity of Whole Blood Clots

2. DX-9065a, an Orally Active, Specific Inhibitor of Factor Xa, Inhibits Thrombosis without Affecting Bleeding Time in Rats

3. Antithrombotic and Hemorrhagic Effects of DX-9065a, a Direct and Selective Factor Xa Inhibitor: Comparison with a Direct Thrombin Inhibitor and Antithrombin Ill-Dependent Anticoagulants

4. Thrombin and factor Xa inhibitors

5. Synthesis and Conformational Analysis of a Non-Amidine Factor Xa Inhibitor That Incorporates 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine as S4 Binding Element

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