Synthesis and evaluation of phenylimidazole FabK inhibitors as new Anti-C. Difficile agents

Author:

Norseeda KrissadaORCID,Bin Aziz Pavel Fahad,Rutherford Jacob T.ORCID,Meer Humna N.,Dureja Chetna,Hurdle Julian G.,Hevener Kirk E.ORCID,Sun DianqingORCID

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference47 articles.

1. Centers for Disease Control and Prevention (CDC), What is C. diff? (www.cdc.gov/cdiff/what-is.html), Accessed January 27, 2023.

2. Clostridium difficile infection;Smits;Nature Reviews Disease Primers,2016

3. Progress in the Discovery of Treatments for C. difficile Infection: A Clinical and Medicinal Chemistry Review;Tsutsumi;Current Topics in Medicinal Chemistry,2014

4. 2019 AR Threats Report (https://www.cdc.gov/drugresistance/biggest-threats.html#cdiff), Accessed January 8, 2023.

5. Clinical Practice Guideline by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA): 2021 Focused Update Guidelines on Management of Clostridioides difficile Infection in Adults;Johnson;Clinical Infectious Diseases,2021

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