A novel survivin dimerization inhibitor without a labile hydrazone linker induces spontaneous apoptosis and synergizes with docetaxel in prostate cancer cells

Author:

Peery Robert,Cui Qingbin,Kyei-Baffour Kwaku,Josephraj Sophia,Huang Caoqinglong,Dong Zizheng,Dai Mingji,Zhang Jian-Ting,Liu Jing-Yuan

Funder

National Institutes of Health

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference26 articles.

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2. Transgenic expression of survivin in keratinocytes counteracts UVB-induced apoptosis and cooperates with loss of p53;Grossman;J Clin Invest,2001

3. IAP proteins: blocking the road to death's door;Salvesen;Nat Rev Mol Cell Biol,2002

4. Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions;Chantalat;Mol Cell,2000

5. IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs;Tamm;Cancer Res,1998

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