From lead optimization to NDA approval for a new antimicrobial: Use of pre-clinical effect models and pharmacokinetic/pharmacodynamic mathematical modeling-Reference-Cited by-同舟云学术

From lead optimization to NDA approval for a new antimicrobial: Use of pre-clinical effect models and pharmacokinetic/pharmacodynamic mathematical modeling

Published:2016-12 Issue:24 Volume:24 Page:6401-6408
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Drusano G.L.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference17 articles.

1. Meropenem Penetration into Epithelial Lining Fluid in Mice and Humans and Delineation of Exposure Targets

2. Optimization of Meropenem Minimum Concentration/MIC Ratio To Suppress In Vitro Resistance of Pseudomonas aeruginosa

3. Emergence of Resistance to Imipenem During Therapy for Pseudomonas aeruginosa Infections

4. Emergence of resistance to carbapenem antibiotics in Pseudomonas aeruginosa

5. Interaction of Drug- and Granulocyte-Mediated Killing of Pseudomonas aeruginosa in a Murine Pneumonia Model

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