A novel 3-arylethynyl-substituted pyrido[2,3,-b]pyrazine derivatives and pharmacophore model as Wnt2/β-catenin pathway inhibitors in non-small-cell lung cancer cell lines-Reference-Cited by-同舟云学术

A novel 3-arylethynyl-substituted pyrido[2,3,-b]pyrazine derivatives and pharmacophore model as Wnt2/β-catenin pathway inhibitors in non-small-cell lung cancer cell lines

Published:2011-09 Issue:18 Volume:19 Page:5639-5647
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Gong Young-Dae,Dong Mi-Sook,Lee Sang-Bum,Kim Nayeon,Bae Mi-Seon,Kang Nam-Sook

Funder

National R&D Program for Cancer Control

Seoul Research and Business Development Program

National Research Foundation of Korea

Ministry of Education, Science and Technology

Ministry of Knowledge Economy

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference32 articles.

1. WNTs modulate cell fate and behavior during vertebrate development

2. WNT targets: repression and activation

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4. Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

5. Wnt signaling pathway and lung disease

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