Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats-Reference-Cited by-同舟云学术

Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats

Published:2011-05 Issue:10 Volume:19 Page:3039-3053
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Bengtsson Christoffer,Blaho Stefan,Saitton David Blomberg,Brickmann Kay,Broddefalk Johan,Davidsson Öjvind,Drmota Tomas,Folmer Rutger,Hallberg Kenth,Hallén Stefan,Hovland Ragnar,Isin Emre,Johannesson Petra,Kull Bengt,Larsson Lars-Olof,Löfgren Lars,Nilsson Kristina E.,Noeske Tobias,Oakes Nick,Plowright Alleyn T.,Schnecke Volker,Ståhlberg Pernilla,Sörme Pernilla,Wan Hong,Wellner Eric,Öster Linda

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference38 articles.

1. Data was obtained from the World Health Organization website: http://www.who.int/diabetes/en/.

2. Review of recent acetyl-CoA carboxylase inhibitor patents: mid-2007 – 2008

3. Acetyl Coenzyme A Carboxylase System of Escherichia coli

4. Isozyme-nonselective N-Substituted Bipiperidylcarboxamide Acetyl-CoA Carboxylase Inhibitors Reduce Tissue Malonyl-CoA Concentrations, Inhibit Fatty Acid Synthesis, and Increase Fatty Acid Oxidation in Cultured Cells and in Experimental Animals

5. Treating the metabolic syndrome: acetyl-CoA carboxylase inhibition

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