Asymmetric synthesis of the four diastereoisomers of a novel non-steroidal farnesoid X receptor (FXR) agonist: Role of the chirality on the biological activity-Reference-Cited by-同舟云学术

Asymmetric synthesis of the four diastereoisomers of a novel non-steroidal farnesoid X receptor (FXR) agonist: Role of the chirality on the biological activity

Published:2013-07 Issue:13 Volume:21 Page:3780-3789
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Marinozzi Maura,Carotti Andrea,Sardella Roccaldo,Buonerba Federica,Ianni Federica,Natalini Benedetto,Passeri Daniela,Rizzo Giovanni,Pellicciari Roberto

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference48 articles.

1. Endogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR

2. Bile Acids: Natural Ligands for an Orphan Nuclear Receptor

3. Identification of a Nuclear Receptor for Bile Acids

4. Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis

5. Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors

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