Structure-activity relationship and mechanistic studies for a series of cinnamyl hydroxamate histone deacetylase inhibitors

Author:

Tavares Maurício Temotheo,de Almeida Larissa Costa,Kronenberger Thales,Monteiro Ferreira Glaucio,Fujii de Divitiis Thainá,Franco Zannini Junqueira Toledo Mônica,Mariko Aymoto Hassimotto Neuza,Agostinho Machado-Neto João,Veras Costa-Lotufo Letícia,Parise-Filho Roberto

Funder

FAPESP

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference80 articles.

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2. IARC CancerBase. CANCER TODAY Data visualization tools for exploring the global cancer burden in 2018. https://gco.iarc.fr/today/home. Published 2018.

3. The role of histone deacetylases (HDACs) in human cancer;Ropero;Mol Oncol,2007

4. Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer;Fraga;Nat Genet,2005

5. Trend of histone deacetylase inhibitors in cancer therapy: isoform selectivity or multitargeted strategy;Zhang;Med Res Rev,2015

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