2-Aminopyridines with a shortened amino sidechain as potent, selective, and highly permeable human neuronal nitric oxide synthase inhibitors

Author:

Vasu Dhananjayan,Li Huiying,Hardy Christine D.,Poulos Thomas L.,Silverman Richard B.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference54 articles.

1. Nitric oxide: a new paradigm for second messengers;Kerwin;J. Med. Chem.,1995

2. Blocking NO synthesis: how, where and why?;Vallance;Nat. Rev. Drug Discovery,2002

3. Nitric oxide: a radical neurotransmitter in the central nervous system;Vincent;Prog. Neurobiol.,1994

4. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor;Palmer;Nature,1987

5. Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates;Ignarro;J. Pharmacol. Exp. Ther.,1981

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