Structure–activity relationship-guided development of retinoic acid receptor-related orphan receptor gamma (RORγ)-selective inverse agonists with a phenanthridin-6(5H)-one skeleton from a liver X receptor ligand-Reference-Cited by-同舟云学术

Structure–activity relationship-guided development of retinoic acid receptor-related orphan receptor gamma (RORγ)-selective inverse agonists with a phenanthridin-6(5H)-one skeleton from a liver X receptor ligand

Published:2014-05 Issue:9 Volume:22 Page:2799-2808
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Nishiyama Yuko,Nakamura Masahiko,Misawa Takashi,Nakagomi Madoka,Makishima Makoto,Ishikawa Minoru,Hashimoto Yuichi

Funder

Ministry of Education, Culture, Sports, Sciences and Technology, Japan

Japan Society for the Promotion of Science

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference28 articles.

2. In vitro and in vivo evidence for orphan nuclear receptor RORalpha function in bone metabolism

3. Disruption of retinoid-related orphan receptor β changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice

4. Retinoic acid-related orphan receptors α and γ: key regulators of lipid/glucose metabolism, inflammation, and insulin sensitivity

5. T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

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