( R )-3-Amino-1-((3a S ,7a S )-octahydro-1 H -indol-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one derivatives as potent inhibitors of dipeptidyl peptidase-4: Design, synthesis, biological evaluation, and molecular modeling-Reference-Cited by-同舟云学术

( R )-3-Amino-1-((3a S ,7a S )-octahydro-1 H -indol-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one derivatives as potent inhibitors of dipeptidyl peptidase-4: Design, synthesis, biological evaluation, and molecular modeling

Published:2014-12 Issue:23 Volume:22 Page:6684-6693
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Wang Sinan,Su Mingbo,Wang Jiang,Li Zeng,Zhang Lei,Ji Xun,Li Jingya,Li Jia,Liu Hong

Funder

National Natural Science Foundation of China

National S&T Major Projects

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference28 articles.

1. Diabetes Mellitus: Pathogenesis and Treatment Strategies

2. Diabetes and Atherosclerosis

3. Type 2 Diabetes Comorbidities and Treatment Challenges: Rationale for DPP-4 Inhibitors

4. Development of Glucagon-Like Peptide-1-Based Pharmaceuticals as Therapeutic Agents for the Treatment of Diabetes

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