Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2-Reference-Cited by-同舟云学术

Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2

Published:2017-12 Issue:24 Volume:25 Page:6479-6485
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

LaRochelle Jonathan R.,Fodor Michelle,Ellegast Jana M.,Liu Xiaoxi,Vemulapalli Vidyasiri,Mohseni Morvarid,Stams Travis,Buhrlage Sara J.,Stegmaier Kimberly,LaMarche Matthew J.,Acker Michael G.,Blacklow Stephen C.

Funder

Novartis-Dana Farber Cancer Institute Drug Development Program

William Lawrence-Blanche Hughes Foundation

American Cancer Society

Novartis Institutes for Biomedical Research

U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, by Argonne National Laboratory

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference24 articles.

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2. PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase;Chan;Blood,2007

3. Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation;Noguchi;Mol Cell Biol,1994

4. PD-1/SHP-2 inhibits Tc1/Th1 phenotypic responses and the activation of T cells in the tumor microenvironment;Li;Cancer Res,2015

5. The tyrosine phosphatase Shp2 (PTPN11) in cancer;Chan;Cancer Metastasis Rev,2008

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