Synthesis, Pim kinase inhibitory potencies and in vitro antiproliferative activities of diversely substituted pyrrolo[2,3-a]carbazoles-Reference-Cited by-同舟云学术

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Synthesis, Pim kinase inhibitory potencies and in vitro antiproliferative activities of diversely substituted pyrrolo[2,3-a]carbazoles

Published:2010-09 Issue:18 Volume:18 Page:6865-6873
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Akué-Gédu Rufine,Nauton Lionel,Théry Vincent,Bain Jenny,Cohen Philip,Anizon Fabrice,Moreau Pascale

Funder

Région Auvergne

PRAI e-nnovergne LifeGrid

European Union Prokinase Research Consortium

CNRS Valorisation

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference24 articles.

1. Structure-based design of 3-aryl-6-amino-triazolo[4,3-b]pyridazine inhibitors of Pim-1 kinase

2. Pim Kinases Promote Cell Cycle Progression by Phosphorylating and Down-regulating p27Kip1 at the Transcriptional and Posttranscriptional Levels

3. Structure and Substrate Specificity of the Pim-1 Kinase

4. Macdonald, A.; Campbell, D. G.; Toth, R.; McLauchlan, H.; Hastie, C. J.; Arthur, J. S. C. BMC Cell Biol. 2006, 7, doi:10.1186/1471-2121-7-1.

5. Isoxazolo[3,4-b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: Chemistry, biological activities, and molecular modeling

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2. Combining machine learning and structure-based approaches to develop oncogene PIM kinase inhibitors;Frontiers in Chemistry;2023-03-10

3. Nicotinonitrile-derived apoptotic inducers: Design, synthesis, X-ray crystal structure and Pim kinase inhibition;Bioorganic Chemistry;2022-12

4. Progress in Annulative Transformations from Indoles to Carbazoles: State of the Art;Chinese Journal of Organic Chemistry;2021

5. Discovery of SARxxxx92, a pan-PIM kinase inhibitor, efficacious in a KG1 tumor model;Bioorganic & Medicinal Chemistry Letters;2020-12

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