Discovery of GS-9131: Design, synthesis and optimization of amidate prodrugs of the novel nucleoside phosphonate HIV reverse transcriptase (RT) inhibitor GS-9148-Reference-Cited by-同舟云学术

Discovery of GS-9131: Design, synthesis and optimization of amidate prodrugs of the novel nucleoside phosphonate HIV reverse transcriptase (RT) inhibitor GS-9148

Published:2010-05 Issue:10 Volume:18 Page:3606-3617
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Mackman Richard L.,Ray Adrian S.,Hui Hon C.,Zhang Lijun,Birkus Gabriel,Boojamra Constantine G.,Desai Manoj C.,Douglas Janet L.,Gao Ying,Grant Deborah,Laflamme Genevieve,Lin Kuei-Ying,Markevitch David Y.,Mishra Ruchika,McDermott Martin,Pakdaman Rowchanak,Petrakovsky Oleg V.,Vela Jennifer E.,Cihlar Tomas

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference26 articles.

1. http://www.who.int/hiv/data/2008_global_summary_AIDS_ep.png.

2. Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV

3. Treatment for Adult HIV Infection

4. A syndrome of lipoatrophy, lactic acidaemia and liver dysfunction associated with HIV nucleoside analogue therapy: contribution to protease inhibitor-related lipodystrophy syndrome

5. Clinical manifestations and management of antiretroviral nucleoside analog-related mitochondrial toxicity

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