Design of potent bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase via targeted interactions with the active site ‘capping’ phenyls-Reference-Cited by-同舟云学术

Design of potent bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase via targeted interactions with the active site ‘capping’ phenyls

Published:2012-09 Issue:18 Volume:20 Page:5583-5591
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

De Schutter Joris W.,Shaw Joseph,Lin Yih-Shyan,Tsantrizos Youla S.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference26 articles.

1. Targeting protein prenylation for cancer therapy

2. Structural Basis for the Exceptional in vivo Efficacy of Bisphosphonate Drugs

3. The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs

4. A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen-containing bisphosphonates

5. The level of ATP analog and isopentenyl pyrophosphate correlates with zoledronic acid-induced apoptosis in cancer cells in vitro

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