The discovery of (1R, 3R)-1-(3-chloro-5-fluorophenyl)-3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-6-carbonitrile, a potent and selective agonist of human transient receptor potential cation channel subfamily m member 5 (TRPM5) and evaluation of as a potential gastrointestinal prokinetic agent

Author:

Sabat M.,Raveglia L.F.,Aldegheri L.,Barilli A.,Bianchi F.,Brault L.,Brodbeck D.,Feriani A.,Lingard I.,Miura J.,Myers R.,Piccoli L.,Tassini S.,Tyhonas J.,Ton-Nu T.,Wang H.,Virginio C.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

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