Structure simplification of the Securinine skeleton reveals the importance of BCD ring system for the cytotoxic activity on HCT116 and HL60 cell lines-Reference-Cited by-同舟云学术

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Structure simplification of the Securinine skeleton reveals the importance of BCD ring system for the cytotoxic activity on HCT116 and HL60 cell lines

Published:2022-03 Issue: Volume:58 Page:116658
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Le Roch Myriam,Afonso Damien,Chirkin Egor,Guillory Xavier,Porée François-Hugues

Funder

Fondation ARC pour la Recherche sur le Cancer

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference65 articles.

1. Elsevier, 1973, Vol. 14, pp 425-506. (b) Chirkin, E.

2. (a) Snieckus, V. The Securinega Alkaloids. In The Alkaloids: Chemistry and Physiology; Elsevier, 1973, Vol. 14, pp 425-506.

3. (b) Chirkin, E.; Atkatlian, W.; Porée, F.-H. The Securinega Alkaloids. In The Alkaloids; Knölker, H.-J., Ed.; 2015 74, pp 1-120.

4. For recent achievements, see: (a) Fan, Z.; Jaisi, A.; Chen, Y.; Shen, L.; Liu, Z.; Wu, S.; Liu, Y.; Zhang, W.; Xiao, Y. Discovery and biosynthesis of ascorbylated Securinega alkaloids. ACS Catal. 2021, 11, 8818-8828.

5. Ye, W.-C. Discovery of neuritogenic Securinega alkaloids from Flueggea suffruticosa by a building blocks-based molecular network strategy. Angew. Chem. Int. Ed. 2021, 60, 19609-19613. (c) Park, K.J.

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