Design, synthesis and biological evaluation of 4-aminopyrimidine-5-cabaldehyde oximes as dual inhibitors of c-Met and VEGFR-2-Reference-Cited by-同舟云学术

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Design, synthesis and biological evaluation of 4-aminopyrimidine-5-cabaldehyde oximes as dual inhibitors of c-Met and VEGFR-2

Published:2016-08 Issue:16 Volume:24 Page:3353-3358
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Qiang Hao,Gu Weijie,Huang DanDan,Shi Wei,Qiu Qianqian,Dai Yuxuan,Huang Wenlong,Qian Hai

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

State Key Laboratory of Natural Medicines

China Pharmaceutical University

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference26 articles.

1. A Novel Inhibitor of c-Met and VEGF Receptor Tyrosine Kinases with a Broad Spectrum of In Vivo Antitumor Activities

2. Targeting MET in cancer: rationale and progress

3. Targeting the HGF/Met signalling pathway in cancer

4. Drug development of MET inhibitors: targeting oncogene addiction and expedience

5. Novel Therapeutic Inhibitors of the c-Met Signaling Pathway in Cancer

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1. Advances in Small-Molecule Dual Inhibitors Targeting EGFR and HER2 Receptors as Anti-Cancer Agents;Current Medicinal Chemistry;2024-06-10

2. Novel substituted 4-(Arylethynyl)-Pyrrolo[2,3-d]pyrimidines negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 5 (mGlu5) Treat depressive disorder in mice;European Journal of Medicinal Chemistry;2023-12

3. The Fundamental Role of Oxime and Oxime Ether Moieties in Improving the Physicochemical and Anticancer Properties of Structurally Diverse Scaffolds;International Journal of Molecular Sciences;2023-11-28

4. Discovery of New Quinazoline Derivatives as VEGFR-2 Inhibitors: Design, Synthesis, and Anti-proliferative Studies;Anti-Cancer Agents in Medicinal Chemistry;2023-11

5. Novel 3-phenylquinazolin-2,4(1H,3H)-diones as dual VEGFR-2/c-Met-TK inhibitors: design, synthesis, and biological evaluation;Scientific Reports;2023-10-30

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