Exploration of pyrrole derivatives to find an effective potassium-competitive acid blocker with moderately long-lasting suppression of gastric acid secretion

Author:

Nishida Haruyuki,Fujimori Ikuo,Arikawa Yasuyoshi,Hirase Keizo,Ono Koji,Nakai Kazuo,Inatomi Nobuhiro,Hori Yasunobu,Matsukawa Jun,Fujioka Yasushi,Imanishi Akio,Fukui Hideo,Itoh Fumio

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference21 articles.

1. H+/K+ ATPase inhibitors in the treatment of acid-related disorders;Bamford;Prog Med Chem,2009

2. K-ATPase as therapeutic target;Sachs;Ann Rev Pharmacal Taxical.,1988

3. Possible mechanism for the inhibition of gastric (H+ + K+)-adenosine triphosphatase by the proton pump inhibitor AG-1749;Nagaya;J Pharmacol Exp Ther,1989

4. Acid suppression: optimizing therapy for gastroduodenal ulcer healing, gastroesophageal reflux disease, and stress-related erosive syndrome;Wolfe;Gastroenterology,2000

5. Chemistry of covalent inhibition of the gastric (H+, K+)-ATPase by proton pump inhibitors;Shin;J Am Chem Soc,2004

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