Design, synthesis and biological evaluation of 3-hydroxyquinazoline-2,4(1H,3H)-diones as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and integrase-Reference-Cited by-同舟云学术

Design, synthesis and biological evaluation of 3-hydroxyquinazoline-2,4(1H,3H)-diones as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and integrase

Published:2019-09 Issue:17 Volume:27 Page:3836-3845
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Gao Ping,Cheng Xiqiang,Sun Lin,Song Shu,Álvarez Mar,Luczkowiak Joanna,Pannecouque Christophe,De Clercq Erik,Menéndez-Arias Luis,Zhan Peng,Liu Xinyong

Funder

National Natural Science Foundation of China

Key Project of NSFC for International Cooperation

Key Research and Development Project of Shandong Province

Young Scholars Program of Shandong University

Major Project of Science and Technology of Shandong Province

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference31 articles.

1. UNAIDS. UNAIDS Data 2018 (2018), World Health Organization, Geneva, Switzerland.

2. Anti-HIV drug discovery and development: current innovations and future trends;Zhan;J Med Chem,2016

3. Molecular basis of human immunodeficiency virus type 1 drug resistance: overview and recent developments;Menéndez-Arias;Antiviral Res,2013

4. Viral reverse transcriptases;Menéndez-Arias;Virus Res,2017

5. Crystal structure of the ribonuclease H domain of HIV-1 reverse transcriptase;Davies;Science (New York, N.Y.),1991

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