Design, synthesis and biological evaluation of sulfonamide-substituted diphenylpyrimidine derivatives (Sul-DPPYs) as potent focal adhesion kinase (FAK) inhibitors with antitumor activity-Reference-Cited by-同舟云学术

Design, synthesis and biological evaluation of sulfonamide-substituted diphenylpyrimidine derivatives (Sul-DPPYs) as potent focal adhesion kinase (FAK) inhibitors with antitumor activity

Published:2017-08 Issue:15 Volume:25 Page:3989-3996
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Qu Menghua,Liu Zhihao,Zhao Dan,Wang Changyuan,Zhang Jianbin,Tang Zeyao,Liu Kexin,Shu Xiaohong,Yuan Hong,Ma Xiaodong

Funder

National Natural Science Foundation of China

Cultivation Project of Youth Techstars

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference28 articles.

1. Signal transduction by focal adhesion kinase in cancer

2. TAE226-mediated inhibition of focal adhesion kinase interferes with tumor angiogenesis and vasculogenesis

3. Focal adhesion kinase inhibitors are potent anti-angiogenic agents

4. Mammary Epithelial-Specific Ablation of the Focal Adhesion Kinase Suppresses Mammary Tumorigenesis by Affecting Mammary Cancer Stem/Progenitor Cells

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