Synthesis and biological evaluation of hybrids from optically active ring-opened 3-N-butylphthalide derivatives and 4-fluro-edaravone as potential anti-acute ischemic stroke agents

Author:

Jia Jian,Wu Jianbing,Ji Duorui,Jiao Weijie,Wang Xiaoli,Huang Zhangjian,Zhang Yihua

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference27 articles.

1. Evolving treatments for acute ischemic stroke;Zerna;Circ Res,2016

2. Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation;Chamorro;Lancet Neurol,2016

3. Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke;Saver;N Engl J Med,2015

4. From seeds of apium graveolens Linn. to a cerebral ischemia medicine: the long journey of 3-n-Butylphthalide;Marco-Contelles;J Med Chem,2020

5. Meta-analysis of effect of dl-3-butylphthalide injection on neurological function of patients with acute cerebral infarction;Xie;Chin J New Drugs Clin Rem,2016

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