Purinylpyridinylamino-based DFG-in/αC-helix-out B-Raf inhibitors: Applying mutant versus wild-type B-Raf selectivity indices for compound profiling-Reference-Cited by-同舟云学术

Purinylpyridinylamino-based DFG-in/αC-helix-out B-Raf inhibitors: Applying mutant versus wild-type B-Raf selectivity indices for compound profiling

Published:2016-05 Issue:10 Volume:24 Page:2215-2234
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Liu Longbin,Lee Matthew R.,Kim Joseph L.,Whittington Douglas A.,Bregman Howard,Hua Zihao,Lewis Richard T.,Martin Matthew W.,Nishimura Nobuko,Potashman Michele,Yang Kevin,Yi Shuyan,Vaida Karina R.,Epstein Linda F.,Babij Carol,Fernando Manory,Carnahan Josette,Norman Mark H.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference54 articles.

1. Targeting the mitogen-activated protein kinase cascade to treat cancer

2. Mutations of the BRAF gene in human cancer

3. High frequency of BRAF mutations in nevi

4. Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF

Cited by 15 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Targeted Therapy Innovations for Melanoma;Hematology/Oncology Clinics of North America;2024-10

2. New Approaches to Targeted Therapy in Melanoma;Cancers;2023-06-17

3. Current Insights into the Role of BRAF Inhibitors in Treatment of Melanoma;Anti-Cancer Agents in Medicinal Chemistry;2023-02

4. New Potential Agents for Malignant Melanoma Treatment—Most Recent Studies 2020–2022;International Journal of Molecular Sciences;2022-05-29

5. Design and Synthesis of Hsp90 Inhibitors with B‐Raf and PDHK1 Multi‐Target Activity;ChemistryOpen;2021-10-11