Synthesis and evaluation of 18F labeled crizotinib derivative [18F]FPC as a novel PET probe for imaging c-MET-positive NSCLC tumor

Author:

Lin Qingyu,Zhang Yingying,Fu Zhequan,Hu Bingxin,Si Zhan,Zhao Yanzhao,Shi Hongcheng,Cheng Dengfeng

Funder

National Natural Science Foundation of China

Shanghai Sailing Program

Open Large Infrastructure Research of Chinese Academy of Science

Shanghai Municipal Key Clinical Specialty

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference31 articles.

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2. Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET;Naldini;Oncogene,1991

3. c-MET as a potential therapeutic target and biomarker in cancer;Sierra;Ther Adv Med Oncol,2011

4. c-MET/phospho-MET protein expression and MET gene copy number in non-small cell lung carcinomas;Tsuta;J Thorac Oncol,2012

5. Randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-sma ll-cell lung cancer;Sequist;J Clin Oncol,2011

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