Integrating a phenotypic screening with a structural simplification strategy to identify 4-phenoxy-quinoline derivatives to potently disrupt the mitotic localization of Aurora kinase B-Reference-Cited by-同舟云学术

Integrating a phenotypic screening with a structural simplification strategy to identify 4-phenoxy-quinoline derivatives to potently disrupt the mitotic localization of Aurora kinase B

Published:2023-02 Issue: Volume:80 Page:117173
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Lv Gang,Shi Qiong,Zhang Ting,Li Jinhua,Long Yan,Zhang Wenhui,Choudhry Namrta,Yang Kevin,Li Hongmei,Kalashova Julia,Yang Chenglu,Zhou Xiaohu,Reddy Mallu Chenna,Anantoju Kishore Kumar,Zhang Shenqiu,Zhang Jing,Allen Thaddeus D.^ORCID,Liu Hong,Nimishetti Naganna,Yang Dun^ORCID

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference44 articles.

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2. The chromosomal passenger complex (CPC) as a key orchestrator of orderly mitotic exit and cytokinesis;Kitagawa;Front Cell DevBiol,2015

3. The chromosomal passenger complex (CPC): From easy rider to the godfather of mitosis;Carmena;Nat Rev Mol Cell Biol,2012

4. Aurora A Kinase Is a Priority Pharmaceutical Target for the Treatment of Cancers;Damodaran;Trends Pharmacol Sci,2017

5. Therapeutic potential of a synthetic lethal interaction between the MYC proto-oncogene and inhibition of aurora-B kinase;Yang;PNAS,2010

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1. Innovating cancer drug discovery with refined phenotypic screens;Trends in Pharmacological Sciences;2024-08

2. Current updates on green synthesis and biological properties of 4-quinolone derivatives;Journal of Molecular Structure;2023-12

3. The Aurora kinase B relocation blocker LXY18 triggers mitotic catastrophe selectively in malignant cells;PLOS ONE;2023-10-30

4. In-vitro metabolism of LXY18, an orally available, potent blocker of AURKB relocation in mitosis;Journal of Pharmaceutical and Biomedical Analysis;2023-08

5. Orally Bioavailable 4-Phenoxy-quinoline Compound as a Potent Aurora Kinase B Relocation Blocker for Cancer Treatment;ACS Pharmacology & Translational Science;2023-07-21