Discovery of novel 5-oxa-2,6-diazaspiro[3.4]oct-6-ene derivatives as potent, selective, and orally available somatostatin receptor subtype 5 (SSTR5) antagonists for treatment of type 2 diabetes mellitus-Reference-Cited by-同舟云学术

Discovery of novel 5-oxa-2,6-diazaspiro[3.4]oct-6-ene derivatives as potent, selective, and orally available somatostatin receptor subtype 5 (SSTR5) antagonists for treatment of type 2 diabetes mellitus

Published:2017-08 Issue:15 Volume:25 Page:4175-4193
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Hirose Hideki,Yamasaki Takeshi,Ogino Masaki,Mizojiri Ryo,Tamura-Okano Yumiko,Yashiro Hiroaki,Muraki Yo,Nakano Yoshihide,Sugama Jun,Hata Akito^ORCID,Iwasaki Shinji,Watanabe Masanori,Maekawa Tsuyoshi,Kasai Shizuo

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference35 articles.

1. Type 2 diabetes mellitus: a review of current trends;Olokoba;Oman Med J,2012

2. Mechanisms of diabetic complications;Forbes;Physiol Rev,2013

3. The current drug treatment landscape for diabetes and perspectives for the future;Bailey;Clin Pharmacol Ther,2015

4. Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone;Brazeau;Science,1973

5. Somatostatin: the neuroendocrine story;Gillies;Trends Pharmacol Sci,1997

Cited by 21 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Agonists, Antagonists and Receptors of Somatostatin: Pathophysiological and Therapeutical Implications in Neoplasias;Current Issues in Molecular Biology;2024-09-02

2. Oral SSTR5 Antagonist SCO‐240 for Growth Hormone Stimulation: A Phase I Single‐Dose Study in Healthy Individuals;Clinical Pharmacology & Therapeutics;2024-03-28

3. Discovery and exploration of novel somatostatin receptor subtype 5 (SSTR5) antagonists for the treatment of cholesterol gallstones;European Journal of Medicinal Chemistry;2024-01

4. Synthesis of Spirocyclic and Fused Isoxazoline Building Blocks;European Journal of Organic Chemistry;2023-05-19

5. Selective somatostatin receptor 5 inhibition improves hepatic insulin sensitivity;Pharmacology Research & Perspectives;2022-12-30