Computer-aided directed evolution ofl-threonine aldolase for asymmetric biocatalytic synthesis of a chloramphenicol intermediate

Author:

Cai Baoqin,Bocola Marco,Zhou Ameng,Sun Fenshuai,Xu Qing,Yang Jiadong,Shen Tianran,Zhang Zhaoqi,Sun Lei,Ji Yaoyao,Bong Yong Koy,Daussmann Thomas,Chen Haibin

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference37 articles.

1. An L-threonine aldolase for asymmetric synthesis of β-hydroxy-α-amino acids;Wang;Chem Eng Sci,2020

2. Enzymatic synthesis of β-hydroxy-α-amino acids based on recombinant D- and L-threonine aldolases;Kimura;J Am Chem Soc,1997

3. Design and synthesis of novel chloramphenicol amine derivatives as potent aminopeptidase N (APN/CD13) inhibitors;Yang;Bioorg Med Chem,2009

4. Identification and application of threonine aldolase for synthesis of valuable α-amino, β-hydroxy-building blocks;Ligibel;Biochim Biophys Acta BBA - Proteins Proteomics,2020

5. Threonine aldolases - an emerging tool for organic synthesis;Steinreiber;Tetrahedron,2007

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