Design and synthesis of 6-fluoro-2-naphthyl derivatives as novel CCR3 antagonists with reduced CYP2D6 inhibition-Reference-Cited by-同舟云学术

Design and synthesis of 6-fluoro-2-naphthyl derivatives as novel CCR3 antagonists with reduced CYP2D6 inhibition

Published:2008-09 Issue:18 Volume:16 Page:8607-8618
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Sato Ippei,Morihira Koichiro,Inami Hiroshi,Kubota Hirokazu,Morokata Tatsuaki,Suzuki Keiko,Iura Yosuke,Nitta Aiko,Imaoka Takayuki,Takahashi Toshiya,Takeuchi Makoto,Ohta Mitsuaki,Tsukamoto Shin-ichi

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference24 articles.

1. Pathophysiology of severe asthma

2. Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody.

3. High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines.

4. T Helper Cell Type 2 Cytokine–Mediated Comitogenic Responses and Ccr3 Expression during Differentiation of Human Mast Cells in Vitro

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