Lead optimization of 5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxyhexanamides to reduce a cardiac safety issue: Discovery of DS-8108b, an orally active renin inhibitor-Reference-Cited by-同舟云学术

Lead optimization of 5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxyhexanamides to reduce a cardiac safety issue: Discovery of DS-8108b, an orally active renin inhibitor

Published:2013-06 Issue:11 Volume:21 Page:3175-3196
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Nakamura Yuji,Fujimoto Teppei,Ogawa Yasuyuki,Namiki Hidenori,Suzuki Sayaka,Asano Masayoshi,Sugita Chie,Mochizuki Akiyoshi,Miyazaki Shojiro,Tamaki Kazuhiko,Nagai Yoko,Inoue Shin-ichi,Nagayama Takahiro,Kato Mikio,Chiba Katsuyoshi,Takasuna Kiyoshi,Nishi Takahide

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference32 articles.

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5. Clinical Experience With the Angiotensin II Receptor Antagonist Losartan

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