Synthesis and evaluation of analogs of the phenylpyridazinone NPD-001 as potent trypanosomal TbrPDEB1 phosphodiesterase inhibitors and in vitro trypanocidals-Reference-Cited by-同舟云学术

Synthesis and evaluation of analogs of the phenylpyridazinone NPD-001 as potent trypanosomal TbrPDEB1 phosphodiesterase inhibitors and in vitro trypanocidals

Published:2016-04 Issue:7 Volume:24 Page:1573-1581
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Veerman Johan,van den Bergh Toine,Orrling Kristina M.,Jansen Chimed,Cos Paul,Maes Louis,Chatelain Eric,Ioset Jean-Robert,Edink Ewald E.,Tenor Hermann,Seebeck Thomas,de Esch Iwan,Leurs Rob,Sterk Geert Jan^ORCID

Funder

Bill & Melinda Gates Foundation (BMGF)/United States of AmericaBill & Melinda Gates Foundation (BMGF)/United States of America

Reconstruction Credit Institution-Federal Ministry of Education and Research

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference31 articles.

1. Pharmacological Validation of Trypanosoma brucei Phosphodiesterases as Novel Drug Targets

2. The Human African Trypanosomiasis Control and Surveillance Programme of the World Health Organization 2000–2009: The Way Forward

3. The Burden of Human African Trypanosomiasis

4. The continuing problem of human African trypanosomiasis (sleeping sickness)

5. TheTrypanosoma bruceicAMP phosphodiesterases TbrPDEBl and TbrPDEB2: flagellar enzymes that are essential for parasite virulence

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