Design, synthesis and stepwise optimization of nitrile-based inhibitors of cathepsins B and L-Reference-Cited by-同舟云学术

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Design, synthesis and stepwise optimization of nitrile-based inhibitors of cathepsins B and L

Published:2021-01 Issue: Volume:29 Page:115827
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Cianni Lorenzo,Rocho Fernanda Dos Reis,Bonatto Vinícius,Martins Felipe Cardoso Prado,Lameira Jerônimo,Leitão Andrei,Montanari Carlos A.,Shamim Anwar

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação de Amparo à Pesquisa do Estado de São Paulo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference52 articles.

1. Emerging principles in protease-based drug discovery;Drag;Nat Rev Drug Discov.,2010

2. Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response;Olson;Nat Rev Cancer.,2015

3. The diverse roles of cysteine proteases in parasites and their suitability as drug targets;McKerrow;PLoS Negl Trop Dis.,2018

4. The role of cysteine protease in Alzheimer disease;Hasanbasic;Mater Sociomed.,2016

5. Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis;Dennemärker;Oncogene,2010

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Novel selective proline-based peptidomimetics for human cathepsin K inhibition;Bioorganic & Medicinal Chemistry Letters;2024-09

2. Some morpholine tethered novel aurones: Design, synthesis, biological, kinetic and molecular docking studies;Bioorganic Chemistry;2023-11

3. Nitriles: an attractive approach to the development of covalent inhibitors;RSC Medicinal Chemistry;2023

4. A decennary update on diverse heterocycles and their intermediates as privileged scaffolds for cathepsin B inhibition;International Journal of Biological Macromolecules;2022-12

5. Host Cell Proteases Mediating SARS-CoV-2 Entry: An Overview;Current Topics in Medicinal Chemistry;2022-08

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